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desvenlafaxine will improve the amount or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Keep track of. Desvenlafaxine inhibits CYP2D6; with increased desvenlafaxine doses (ie, four hundred mg) decrease the CYP2D6 substrate dose by approximately fifty%; no dosage adjustment wanted with desvenlafaxine doses seven consec